Introduction
Exposure keratopathy is the drying of the cornea as a result of inability to close the eyelids or blink adequately.
If not detected and treated, this condition can result in corneal ulceration and perforation leading to blindness.
Causes of exposure keratopathy
The following are the causes of EK:
- Facial nerve palsy e.g. Bell’s palsy or leprosy
- Scarring of the eyelids
- Coma
- Thyroid eye disease
- Parkinson’s disease
- Proptosis
- Steven Johnson’s Syndrome
Symptoms of exposure keratopathy
The symptoms of EK are:
- Feeling of drying of the eye
- Foreign body sensations in the eye
- Photophobia
- Blurring of vision
Signs
- Lagophthalmos (inability to close the eyes)
- Incomplete blink (the upper eyelid does not cover the whole cornea during blink)
- Infrequent blink
- Superficial punctate stains on the cornea
- Large coalescent corneal epithelial defect
- Corneal ulceration
- Corneal perforation
Investigations
- Nil
Treatment for exposure keratopathy
Objectives
- To moisten the cornea artificially
- To prevent the complications of dry eyes
Non-pharmacological treatment
- Taping the eyelids closed in the comatose patient
- Partial tarsorrhaphy
- Education of patients with Parkinson’s or thyroid eye disease to blink frequently voluntarily rather than rely on reflex blink
Pharmacological treatment
1st Line Treatment
Evidence Rating: [C]
Hydroxymethyl cellulose, 0.3% eye drops,
- 1-2 hourly during waking time
2nd Line Treatment
Evidence Rating: [C]
Polyvinyl alcohol, 1.4-2% eye drops, 1-2 hourly during waking time
And
Chloramphenicol, 1% eye ointment, at night before bedtime
Or
Tetracycline, 1% eye ointment, at bedtime
Referral Criteria
Refer patients whose exposure keratopathy is not improving to the eye specialist.