Introduction
Hyperemesis gravidarum is a clinical situation in which vomiting in early
pregnancy considered to be physiological
becomes persistent or severe enough to
disturb the patient’s health and/or require hospitalization.
This occurs in approximately a third to 50% of women. It is often the first sign of pregnancy, beginning at about the 6 week and stops spontaneously before the 14thweek.
Generally limited to the early morning, but may occur at other times of the day.
Cause is essentially unknown, but hypotheses include
Hormonal:
- Increased sensitivity to placental
hormones such as hCG, estrogen or
progesterone.
Psychogenic:
- The woman thinks she should have early morning sickness because generations before her have had it.
Clinical features
- Persistent and severe vomiting that leads to electrolyte and nutritional derangements
Differential diagnoses
- It is a diagnosis of exclusion.
- Concerted effort must be made to exclude the under listed causes of pathological vomiting:
- Multiple gestations
- Hydatidiform mole
- Malaria in pregnancy
- Gastrointestinal disorders:
- Heartburn due to hiatus hernia: a common
cause of vomiting in late pregnancy - Enteritis
- Appendicitis
- Peptic ulcer disease
- Hepatitis
- Acute fatty liver of pregnancy
- Pancreatitis
- Cholecystitis
- Heartburn due to hiatus hernia: a common
- Urinary tract disorders:
- pyelonephritis
- Acute polyhydramnios
- Commonly associated with monozygotic twinning and diabetic pregnancies
- Pre-eclampsia
- Accidents to ovarian cysts
- Torsion, haemorrhage, infection and rupture
- Red degeneration in a fibroid
Complications
- Biochemical abnormalities
- Usually sequel to vomiting, starvation and dehydration
- Ketosis, electrolyte imbalance (alkalosis and hypokalemia); vitamin deficiencies
- In neglected or poorly managed cases:
- severe weight loss,
- Tachycardia,
- Hypotension,
- Oliguria
- Neurologic disorders from vitamin deficiency
- Retinal haemorrhages
- Jaundice (from hepatic necrosis)
- Oesophageal tears and spontaneous rupture of the oesophagus
- Mendelson’s syndrome
- Fetal loss
- Maternal mortality
Investigations
- Full Blood Count with differentials
- Urea, Electrolytes and Creatinine
- Liver function tests
- Midstream urine for microscopy culture and sensitivity
- Urinalysis for ketones
- Blood film for malaria parasites
- Ultrasound scan of the pelvis/ abdomen to rule out multiple or abnormal pregnancies
Treatment
A. Mild cases
1st Line Treatment
Evidence Rating: [A]
Metoclopramide, oral, 10 mg 8-12 hourly
2nd Line Treatment
Evidence Rating: [A]
Promethazine theoclate, oral, 25 mg 8-12 hourly
Or
Promethazine hydrochloride, oral, 25 mg 8-12 hourly
B. Severe Cases
Normal saline, IV, (alternate with 5% Dextrose to meet requirements)
Or
Ringers lactate, IV, (alternate with 5% Dextrose to meet require ments)
And
1st Line Treatment
Evidence Rating: [A]
Metoclopramide, IM or IV,
- 5-10 mg 8 hourly;
- If body weight < 60 kg, give 5 mg 8 hourly.
- Do not exceed 500 micro gram/kg in a day
2nd Line Treatment
Evidence Rating: [A]
Ondansetron, oral, IM, IV,
- 4-8 mg 8 hourly as needed
3rd Line Treatment
Evidence Rating: [A]
Promethazine hydrochloride, IM or IV,
- 25 mg 8-12 hourly (max. daily dose, 100 mg)
- Total parenteral nutrition
- In persistent and intractable cases with significant maternal complications, termination of pregnancy may be considered.
Referral Criteria
Refer severe cases with dehydration and/or shock and metabolic disturbances to a hospital for intravenous fluid replacement and antiemetic therapy.